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生理信号测量

大鼠.小鼠无创血压仪MRBP

时间:2016-09-29来源:本站作者:玉研仪器

详细介绍

大小鼠无创血压测量系统(适合对大鼠小鼠进行血压测量,通过对鼠尾根部的实时检测,精确测量出大小鼠的收缩压、舒张压、平均压、心率,敬请来电咨询)

 

美国IITC生命科学仪器公司成立于1973年,其血压测量系统应用于全球的生命科学研究领域,经过不断的改进和拓展无创血压测量系统和测痛产品系列,其产品已用于全球实验室,也被数千篇国际论文所引用。

 

MRBP血压测量系统能够测量最少一只,最多同时200只动物,是全球唯一经过验证的最有效的手段和数据采集法,可以切实协助研究人员快速准确的在最低的推荐温度下对动物进行血压测量。

 

大小鼠无创血压测量系统的主要优势及特点:

 

Ø 仅有的可测量从小鼠、大鼠、豚鼠到猴的血压设备

Ø 采用光电传感技术测量原理,适用于麻醉、清醒状态下的动物血压测量

Ø 内置软件,通过触摸操作屏控制,操作方便。也可通过电脑控制。

Ø 测量参数:收缩压、舒张压、平均压、心率等

Ø 充放气速率1-10 mmHg/秒可调

Ø 自动充放气,尾套气压限值和测试截止压力值均可调,提高测试效率

Ø 血压测量范围:0-300mmHg,精确度±5mmHg

Ø 心率测量范围:0-1000 bpm

Ø 液晶屏实时显示参数测量值和脉搏波形,并能存储、编辑、打印数据

Ø USB直接储存数据功能

Ø 可一次性独立或同时测试多至200只动物

Ø 适用于核磁共振条件(MRI

 

MRBP大小鼠血压计的主要特色:

 

无创血压实验需要提高受测体周围环境的温度。理论上,较高温度时,测量血压的效果很好。我们可以通过控制鼠尾的血量来控制大小鼠的体温。当体温高于正常值时,流经鼠尾的血液就会散掉多余的热量。体温越高流经鼠尾的血液就越多。研究发现,加热大鼠的温度高于32摄氏度、小鼠温度高于34摄氏度时,会产生热应力,动物的热量就会损失一部分。这就影响了真正的血压值(改变了差不多+/-12-28 mmHg

 

检测脉冲的形式非常重要,而传感器的选择决定了制作工艺。压电传感器多年来被广泛应用于麦克风和触碰开关。其原理是:对传感器施加外力后,产生电信号。但用这种传感器作为检测脉冲会有一系列的问题和缺陷:进行血压测量时有较高的温度需求(36-40℃)。

用晶体做的脉冲探测器也会出现一些问题和缺陷:进行鼠类的血压测量时所需要的温度高于热力学水平温度(36-40℃),而且加热尾部是基于尾部脉搏是局部加热的结果这一错误的假设。

 

1978IITC发明了光电传感器,它将光和图片传感器用于脉搏的测量。当血流通过尾部,尾部血管直径的改变导致了光量得改变,直接导致光电量的变化。IITC原件的设计(感应电子设备和咬合袖带)不会像其他仪器一样,会对鼠尾产生机械性的作用力,同时如果需要可以精确地切断传感器。光电传感器可以在封闭的室温下进行检测,事实上许多使用本产品发表过的论文中,小鼠的起测温度要低于28℃,大鼠甚至更低。

 

与其他的高温法相比:

鼠类和其他动物一样有一个内在的调节机制,我们称为“温度调节。正常的环境温度大概在26-27℃,如果环境温度高于正常温度(28-30℃),温度调节开始增加血液流量。这样会导致尾部会有更多的血液流量,由于尾部是身体的一部分而并不是简单的皮革的覆盖,所以会自行降温以求尽快散热。这就是间接测量血压的原理。

MRBP大小鼠血压计最大的不同在于脉搏探测器上。它能在26℃或者更低的温度下进行测量。而其他脉搏探测器由于不够敏感就会要求更高的温度。温度过高会使动物死亡的风险大大增加。

 

部分参考文献:

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Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress

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Protective Effects of At1-Receptor Blocker and Ca Antagonist Combination on Renal Function in Salt Loaded Spontaneously Hypertensive Rats/Протективни Ефекти …

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