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内分泌与代谢研究

大.小鼠清醒动物活动笼

时间:2016-09-20来源:本站作者:玉研仪器

详细介绍

大小鼠清醒动物活动笼 主要应用于大小鼠在微透析或者长期给药过程中,保持自由活动状态。

大鼠微透析笼/大鼠自动给药活动装置可以对清醒状态下的大鼠/小鼠进行长时间的微透析或给药实验。通过容器的旋转来抵消动物活动的产生的转动力,从而使导管和连接线更不致缠结扭曲。配合行为学监测系统还可以监测动物的活动情况,从而研究动物服药前后活动的差异,大大提高了实验人员的工作效率。

大小鼠清醒活动装置可以使大小鼠在微透析或者长期给药过程中,保持自由活动状态。 专利设计的Raturn装置,可以对小动物在清醒状态下进行长时间的微透析实验。通过容器的旋转来抵消动物活动的产生的转动力,从而使导管和连接线更不致缠结扭曲。配合行为学监测系统还可以监测动物的活动情况,从而研究动物服药前后活动的差异,大大提高了实验人员的工作效率。
Raturn装置取代了传统的液体活动臂,保证了连续的液体通路,保证了实验的连续性,并大大延长了清醒活动臂的使用寿命。还可以从动物身上连出多条管线,在一只动物身上完成过去需要多只动物才能完成的实验,并确保了实验的可靠性和实验数据的准确性和稳定性。
Sampling Caging Systems
When sampling from awake, freely moving animals, one must ensure theanimals don’t hurt themselves or damage your sampling lines. BASi offerstwo technologies to achieve this; the Raturn interactive caging system,and liquid swivels. The Raturn System is based on technology developedby BASi. However, as a company that prides itself on satisfying ourcustomers, we want to be sure to offer you the options you desire.Depending on your anticipated experimental goals, you may find it moreuseful to use one type of system over the other. The guide below isintended to help you select the system that best meets your needs.

五通转环是一个具备有低的死体积、小旋转力矩,适合于大、小鼠实验的五通道清醒活动装置。能够满足客户在大鼠清醒活动状态下完成单位点、双位点微透析和多点灌流/体液收集等等同步实验的要求。通道均用特殊材料处理以防止对神经递质或者所观测药物的影响。五通道旋转器包含一个平衡力臂可最小化动物上方垂直的压力。 

液体转环清醒活动系统( Liquid Swivel-based Systems )是由2个小圆柱组成,依靠动 物的拖带转动。它需要实验者非常细心地调节2个小圆柱的紧密度。即解决漏液和转动的矛盾。如果调节密封紧,可以不漏液,但是不容易转动,堵塞管子。如果调节密封松,使转动灵活,但是容易漏液,需要防止2个圆柱之间容易漏液和粘连不动;避免管子堵塞。
 
Liquid Swivel-based Systems
·  Swivel systems have been successfully been used for years byresearchers in pharma, universities, and CROs.
·  Swivels function by using concentric channels for each line thatgoes into or out of the subject. With each channel that is added to theswivel, the dead volume and the resistance to being turned by the animal increases.
·   Swivels contain internal seals which maintain the connection fromthe top of the swivel to the bottom  (these seals require maintenanceafter each use of the swivel).
·  When using a swivel system, it is the swivel itself that turns toprevent twisting of the inlet and outlet lines.
A  liquid swivel  is satisfactory if:
·  You intend to use the system ONLY for a single type of sampling atone time (microdialysis or ultrafiltration or blood sampling)
·  There will only be one or two lines plumbed to/from the animal
·  The ability to upgrade, or add capability to your existing equipmentis not important to you
·  You do not wish to use electrical lead lines
·  You are not interested in collecting automated animal activity data
·  You would like to be able to use a home-cage in your experimentalset-up. (Note: If your animal has a brain microdialysis probe or a guidecannula, we do not recommend sampling in a home cage with a descendingcage lid.)


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