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疼痛与炎症研究

足底痛觉测量仪

时间:2016-09-20来源:本站作者:玉研仪器

详细介绍

足底痛觉测量仪(大小鼠足底热测痛仪,热刺激痛觉测试仪,Hargreaves Method,Plantar Test Apparatus for Mice and Rats)(测试大鼠和小鼠的疼痛反应时间,进行快速精确地筛选麻醉型镇痛药物,更多详情敬请来电咨询)

型号:390型、390G型 

足底痛觉实验用于测试镇痛药物影响无束缚大鼠对外部热刺激的反应时间,使用时先通过从爪下面的测试头发出导向光将光源移到动物爪底,通过反光镜确定位置,避免频繁弯腰和低头,方便操作,启动加热光束照射到动物爪底进行实验。

The Plantar Analgesia Meter for thermal paw can be used on 12 mice, 6 rats and other animals (cats, rabbits) unrestrained when testing for narcotic drugs. Experiments are easy to perform, simply slide the test head under test subject, align the heat source via our exclusive guide light (idle state) by the attached, adjustable, angled mirror on test head to test subject and perform tests.


足底热测痛仪主要特点: 

Ø 精确数字控制, 时间精确度为0.01

Ø 自动切断保护功能

Ø 光束强度可调节,步进量1

Ø 手工结束测试,减少误触发

Ø 强制取消定时器功能

Ø 数字显示功能

Ø 动物不需固定限制

Ø 加热玻璃可选配

Ø 测试头具有反光镜辅助观察

Ø 标准计算机打印口输出

Ø 型号:390 爪刺激痛觉测试仪

Ø 型号:390G 爪刺激痛觉测试仪内置热玻璃

 

足底热测痛仪技术参数:

Ø 可见光法测试、精确数字程控

Ø 适用于小鼠、大鼠、猫、兔等实验动物,动物无需固定全自然状态下测试

Ø 2通道大鼠或4通道小鼠(最多可达6通道大鼠或12通道小鼠)

Ø 刺激光可调,范围从室温~250℃

Ø 计时器精度:0.1

Ø 按钮及脚踏开关控制启动、停止和重设实验

Ø 探视镜及玻璃板角度可调

Ø 引导光线协助定位

Ø 自动断电关闭设计,人道避免动物组织损伤

Ø USB RS232 标准

Ø 电压范围120v~240V

Ø 通过CE认证

Ø 独家选配加热玻璃板,温度调节范围30~40℃

Ø 独家选配数据采集软件


部分参考文献:

Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury
Y Guan, LM Johanek, TV Hartke, B Shim, YX Tao… - Pain, 2008 - Elsevier
... Abrupt paw-withdrawal, licking, and shaking were regarded as positive responses. To test for signs of heat hyperalgesia, paw-withdrawal latencies (PWLs) to radiant heat stimuli [19] were measured with a plantar stimulator analgesia meter (IITC model 390, Woodland Hills, CA). ...


Sex-specificity and estrogen-dependence of kappa opioid receptor-mediated antinociception and antihyperalgesia
KP Lawson, S Nag, AD Thompson, SS Mokha - Pain, 2010 - Elsevier
... 2.8. Paw withdrawal assays. Thermal hyperalgesia was measured using a plantar analgesia meter (IITC model 390, Woodland Hills, CA), as described originally by Hargreaves [25]. Animals were placed in a clear plastic cage


Antinociceptive effects of MSVIII-19, a functional antagonist of the GluK1 kainate receptor
CS Qiu, LLV Wyhe, M Sasaki, R Sakai, GT Swanson… - Pain, 2011 - Elsevier
... Mice were placed in individual 10 × 10 × 15-cm plastic boxes on a glass floor of the apparatus (model 390, IITC Life Science) and allowed to acclimate for at least 30 minutes before drug or vehicle injection. Each paw was tested at least 3 times. ...

Low-frequency electroacupuncture suppresses carrageenan-induced paw inflammation in mice via sympathetic post-ganglionic neurons, while high-frequency EA …
HW Kim, DK Uh, SY Yoon, DH Roh, YB Kwon… - Brain research …, 2008 - Elsevier
... responses to noxious thermal stimuli, paw withdrawal latency was evaluated based on a previously described procedure [8]. Briefly, a radiant heat source was positioned beneath the hind paw in thermal tester (IITC 390 plantar tester, IITC Life Science, Woodland Hills, CA USA). ...

Macrophage inflammatory protein-1α mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1 β up-regulation
N Kiguchi, T Maeda, Y Kobayashi, Y Fukazawa… - Pain, 2010 - Elsevier
... 2.6. Hargreaves test. Thermal hyperalgesia was evaluated by withdrawal latency using the IITC 390 Plantar Test Analgesia Meter (Neuroscience, Tokyo, Japan). Mice were placed on top of a glass sheet, and covered with a clear cage. ...

CC-chemokine MIP-1α in the spinal cord contributes to nerve injury-induced neuropathic pain
N Kiguchi, Y Kobayashi, T Maeda, F Saika… - Neuroscience …, 2010 - Elsevier
... Thermal hyperalgesia was evaluated by withdrawal latency using the IITC 390 Plantar Test Analgesia Meter (Neuroscience). Mice were placed on a glass sheet and covered with a clear cage. Mice were allowed to adapt for 2–3 h before the test. ...

Transient heat hyperalgesia during resolution of ropivacaine sciatic nerve block in the rat
LM Kolarczyk, BA Williams - Regional anesthesia and pain …, 2011 - ncbi.nlm.nih.gov
... min to a raised, fenestrated stainless-steel table (which provided access to the plantar aspect of each hindpaw for application of von Frey monofilaments from below), followed by a minimum of 5 min acclimation on a glass thermal (34°C) table apparatus (IITC® 390 Plantar Test ...

Suppressive effect of imipramine on vincristine-induced mechanical allodynia in mice
F Saika, N Kiguchi, Y Kobayashi, Y Fukazawa… - Biological and …, 2009 - jlc.jst.go.jp
... before morphine administration)(value of % response at 30 min after morphine administration)]/(value of % response before morphine administration) Thermal Paw Withdrawal Test Thermal hyperalgesia was evaluated by withdrawal latency using the IITC 390 Plantar Test ...

CC‐chemokine ligand 4/macrophage inflammatory protein‐1β participates in the induction of neuropathic pain after peripheral nerve injury
F Saika, N Kiguchi, Y Kobayashi… - … Journal of Pain, 2012 - Wiley Online Library
... 2.3 Hargreaves test. Thermal hyperalgesia was evaluated by withdrawal latency using the IITC 390 Plantar Test Analgesia Meter (Neuroscience). The mice were placed on the top of a glass sheet and covered with a clear cage. ...

Epigenetic augmentation of the macrophage inflammatory protein 2/CXC chemokine receptor type 2 axis through histone H3 acetylation in injured peripheral nerves …
N Kiguchi, Y Kobayashi, T Maeda, Y Fukazawa… - … of Pharmacology and …, 2012 - ASPET
... Mice were allowed to adapt for 2 to 3 h before the test. The radiant heat source, IITC 390 Plantar Test Analgesia Meter (Neuroscience), was positioned under the glass sheet and applied to the plantar surface of the hind paw. ...

Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice
N Kiguchi, T Maeda, Y Kobayashi… - Anesthesia & …, 2009 - journals.lww.com
Advertisement. Close Window. Close Window. Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. ...

Learning and memory with neuropathic pain: impact of old age and progranulin deficiency
B Albuquerque, A Häussler, E Vannoni… - Frontiers in …, 2013 - ncbi.nlm.nih.gov
... Heat hyperalgesia was assessed by recording the paw withdrawal latency in the Hargreaves Test (IITC 390 Plantar Test), in which a radiant heat source is placed underneath the hind paw with a mirror system and applies radiant heat upon pressure of a button. ...

Activation of nicotinic acetylcholine receptors on bone marrow-derived cells relieves neuropathic pain accompanied by peripheral neuroinflammation
N Kiguchi, Y Kobayashi, T Maeda, S Tominaga… - Neurochemistry …, 2012 - Elsevier
... The radiant heat source, IITC 390 Plantar Test Analgesia Meter (Neuroscience), was positioned under the glass sheet and applied to the plantar surface of the hind paw. Thermal hyperalgesia was designed as the mean latency of three stimulations. ...

Epigenetic augmentation of the MIP-2/CXCR2 axis through histone H3 acetylation in injured peripheral nerves elicits neuropathic pain
N Kiguchi, Y Kobayashi, T Maeda, Y Fukazawa… - … of Pharmacology and …, 2011 - ASPET
... Mice were allowed to adapt for 2–3 h before the test. The radiant heat source, IITC 390 Plantar Test Analgesia Meter (Neuroscience), was positioned under the glass sheet and applied to the plantar surface of the hind paw. Withdrawal latencies were measured three times ...

A practitioner report on the evaluation of the performance of the C, C++ and Java compilers on the OS/390 platform
DA Cargill, M Radaideh - Performance Analysis of Systems and …, 2000 - ieeexplore.ieee.org
... To do this analysis, we iise tlie pcrformnncc tools availablc on thc OS/390 platihnn, specifically thc PerTonnnncc Analyzcr from IBM [2] atid Strobctg ... I-Iowcver, wc realize that
cotii~~iitc-iiiterisivc bcrichti~irks do iiot STI'CSS he opcratiiig syslcin or llic 110 siibsystciii and iiiay not bc ...

Pentoxifylline attenuates the development of hyperalgesia in a rat model of neuropathic pain
J Liu, X Feng, M Yu, W Xie, X Zhao, W Li, R Guan… - Neuroscience …, 2007 - Elsevier
... Five tests were conducted at intervals of 5 min and the force (g) applied was recorded. Thermal sensitivity was determined by using paw withdrawal latencies to radiant heat (Model 390, IITC Life Science, INC.). After animals ...

Effect of betamethasone on neuropathic pain and cerebral expression of NF-κB and cytokines
W Xie, X Liu, H Xuan, S Luo, X Zhao, Z Zhou, J Xu - Neuroscience letters, 2006 - Elsevier
... The threshold of paw withdrawal to noxious heat stimuli was measured using a paw stimulator analgesia meter (Model 390, IITC Life Science, Inc.). Rats were placed on a 6-mm thick glass floor under an inverted clear Plexiglas cage and were allowed to acclimatize for 10 min. ...

Topical application of l-menthol induces heat analgesia, mechanical allodynia, and a biphasic effect on cold sensitivity in rats
AH Klein, CM Sawyer, MI Carstens… - Behavioural brain …, 2010 - Elsevier
... A light beam (Plantar Test 390, IITC, Woodland Hills, CA) was focused onto the plantar surface of the hind paw through the glass plate from below, and the latency from onset of the light to brisk withdrawal of the stimulated paw was measured. ...

Behavioral evidence of thermal hyperalgesia and mechanical allodynia induced by intradermal cinnamaldehyde in rats
MG Tsagareli, N Tsiklauri, KL Zanotto, MI Carstens… - Neuroscience …, 2010 - Elsevier
... A light beam (Plantar Test 390, IITC, Woodland Hills, CA) was focused onto the plantar surface through the glass floor from below, and the latency from onset of the light to brisk withdrawal of the stimulated paw was measured. ...

Vascular endothelial growth factor signaling in injured nerves underlies peripheral sensitization in neuropathic pain
Tel021-35183767 Http://www.yuyanbio.com
N Kiguchi, Y Kobayashi, Y Kadowaki… - Journal of …, 2014 - Wiley Online Library
... The mice were allowed to adapt for 2–3 h before the test. The radiant heat source, IITC 390 Planter Test Analgesia Meter (Neuroscience), was positioned under the glass sheet and applied to the plantar surface of the hind paw. ...


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